Cannabidiol (CBD)- A Natural Plant Derived Compound


So where does CBD come from? As earlier stated it is a naturally occurring compound present in varieties of Cannabaceae C.. Here's how CBD is created. Its not all done with in the plant. In fact only the carboxylic acid form of cannabidiol (CBDa) is produced inside the glandular trichome while the plant is growing. The final decarboxylation step is chemically a degradation of the carboxyl functional group, because when CBDa is exposed to heat and/or varying amounts of light, carbon dioxide is liberated along with water and hydrogen replaces the carboxyl functional groups position. The resulting substitution creates CBD.

The biosynthesis of CBDa is a complex series of reactions that begins with the medium chain fatty acid hexanoyl-CoA. For simplicity sake, illustrated below is the sequence of reactions where Geranyl pyrophosphate (GPP) and Olivetolic acid bind in the presence of an enzyme referred to as a 
Geranylpyrophosphate--olivetolic acid geranyltransferase (GOT) to form CBGa. CBGa is bound by the enzyme CBD synthase and converted to CBDa. Then finally CBDa is decarboxylated via heat and/or light to form CBD.

  Geranyl pyrophosphate (GPP)

GOT Enzyme       +    
(Olivetolic Acid)
 Cannabigerolic Acid (CBGa)
CBD Synthase
 Cannabidiol Acid (CBDa)Decarboxylation 

 Cannabidiol (CBD)